{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/FT250100879"},"data":{"type":"grant-details","id":"FT250100879","attributes":{"code":"FT250100879","administering-organisation":"Adelaide University","announcement-administering-organisation":"The University of Adelaide","scheme-name":"ARC Future Fellowships","grant-status":"Active","funding-commencement-year":2025,"years-funded":4,"project-start-date":"2026-06-30","anticipated-end-date":"2030-06-29","grant-summary":"Deciphering contextual multi-pathway crosstalk in cellular decision making. This project aims to unravel how cells make decisions by decoding their complex internal communication networks. Like assembling puzzle pieces to form a complete picture, this project will determine how different signalling routes in cells fit together and also how this assembled network functions in different cell types. The project will also develop new methods to map these intricate networks across various cellular contexts and simulate them using computers. The benefit will be new knowledge of how cells process multiple signals to make decisions and new tools enabling more accurate prediction of cell behaviour. These advances will drive innovation in biotechnology, from enhancing biofuel production to developing more resilient crops.","funding-current":1314615.00,"funding-at-announcement":1286791,"investigators-current":[{"title":"Prof","firstName":"Lan","familyName":"Nguyen","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0003-4040-7705 "}],"investigators-at-announcement":[{"title":"Prof","firstName":"Lan","familyName":"Nguyen","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0003-4040-7705 "}],"organisations-current":[{"organisationName":"Adelaide University","roleName":"Administering Organisation","state":"SA"}],"organisations-at-announcement":[{"organisationName":"The University of Adelaide","roleName":"Administering Organisation","state":"SA"}],"field-of-research":[{"isPrimary":true,"code":"3101","name":"Biochemistry and Cell Biology","type":"FOR20"},{"isPrimary":false,"code":"310111","name":"Signal Transduction","type":"FOR20"},{"isPrimary":false,"code":"310114","name":"Systems Biology","type":"FOR20"},{"isPrimary":false,"code":"490102","name":"Biological Mathematics","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"},{"code":"280118","name":"Expanding Knowledge In the Mathematical Sciences","type":"SEO20"}],"international-collaboration":["Japan","Scotland"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"This project aims to determine how cells make decisions by unravelling their complex internal communication networks. Just as a city's traffic system adapts to changing conditions, cellular signalling pathways respond dynamically to their environment. We will develop cutting-edge predictive models and methods to map these intricate networks across various cell types. This will yield two significant outcomes:(1) fundamental knowledge of multi-pathway signalling interactions and the principles governing cellular decision-making; (2) innovative tools enabling researchers and industry to build sophisticated, accurate simulations of cellular behaviour.\nThese advancements will benefit Australians in several ways. Economically, this research will drive innovation in the biotechnology sector by enabling new ways to control how cells behave for industrial applications. For example, we can program cells to grow more efficiently for producing biofuels - a renewable energy source made by microorganisms - helping Australia reduce its reliance on fossil fuels and address climate change. Furthermore, insights into cellular communication could help develop more resilient crops, supporting Australia's agricultural industry.To maximise these benefits and ensure they reach Australians, we will make all computational tools freely available online, partner with Australian biotechnology companies, and train the next generation of interdisciplinary scientists to boost Australia's STEM workforce.\n"}}}