{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/FT250100621"},"data":{"type":"grant-details","id":"FT250100621","attributes":{"code":"FT250100621","administering-organisation":"The University of Queensland","announcement-administering-organisation":"The University of Queensland","scheme-name":"ARC Future Fellowships","grant-status":"Active","funding-commencement-year":2025,"years-funded":4,"project-start-date":"2026-01-19","anticipated-end-date":"2030-01-18","grant-summary":"Novel mechanisms of adhesion assembly and crosstalk in arteries and veins. Arteries and veins are lined by cells with different adhesive properties to facilitate vessel specific barrier physiology. What controls adhesion differences is still poorly understood. This research will apply unique zebrafish models, 3D human micro-vessels, and omics approaches to help solve this knowledge gap in two complementary Programs:\n[P1] Identify how a novel Adrenomedullin-Pim kinase pathway regulates adhesion only in veins \n[P2] Visualise dynamics of adhesive forces in vivo and identify how these forces contribute to barrier function\nThis work will enhance our understanding of blood vessel integrity in different vessel types and expand the scope of Australian research by informing efforts to vascularise engineered tissues.","funding-current":1150587.00,"funding-at-announcement":1126122,"investigators-current":[{"title":"A/Prof","firstName":"Anne Karine","familyName":"Lagendijk","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0003-1246-1608 "}],"investigators-at-announcement":[{"title":"A/Prof","firstName":"Anne Karine","familyName":"Lagendijk","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0003-1246-1608 "}],"organisations-current":[{"organisationName":"The University of Queensland","roleName":"Administering Organisation","state":"QLD"}],"organisations-at-announcement":[{"organisationName":"The University of Queensland","roleName":"Administering Organisation","state":"QLD"}],"field-of-research":[{"isPrimary":true,"code":"3101","name":"Biochemistry and Cell Biology","type":"FOR20"},{"isPrimary":false,"code":"310105","name":"Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall)","type":"FOR20"},{"isPrimary":false,"code":"310503","name":"Developmental Genetics (Incl. Sex Determination)","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"}],"international-collaboration":["France","Switzerland","United States of America"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"The global quest to be able to bioengineer tissues is held back by the current inability to vascularise these ‘organs in a dish’. To address this challenge, we require a deeper understanding of how to generate blood vessels that do not leak. Added complexity to this challenge comes from the fact that we need both arteries and veins that enable delivery and exchange of oxygen and nutrients. However, there are still many questions about how these distinct blood vessels are made during normal organ development. We therefore need to solve this knowledge gap and understand how to generate functional blood vessels. Application of this knowledge will help grow bioengineered tissues that are suited to replace damaged organs and tissues, thereby reducing the economical burden associated with the need for organ transplants. Furthermore, advancing the field of tissue engineering would drive employment and commercial opportunities in biotechnology, medical device development, and research, spurring economic growth.\n\nThis project will use innovative model systems (zebrafish, human engineered vessels) to discover key chemical and physical cues that control differential growth and function of arteries and veins. Chemical compounds that modify these cues already exist and thus new knowledge from this research will provide critical information on the application of such compounds to help create divergent blood vessel types in bioengineered organs and advance the field of tissue engineering."}}}