{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/FT250100533"},"data":{"type":"grant-details","id":"FT250100533","attributes":{"code":"FT250100533","administering-organisation":"La Trobe University","announcement-administering-organisation":"La Trobe University","scheme-name":"ARC Future Fellowships","grant-status":"Active","funding-commencement-year":2025,"years-funded":4,"project-start-date":"2026-01-04","anticipated-end-date":"2030-01-03","grant-summary":"Novel regulators of immune cell development in the digestive tract. This study aims to better understand immune cell development, homeostatic maintenance and essential repair processes in the intestine. This project aims to generate new knowledge of how immune cells of the intestine, known as gamma delta T cells, engage with intestinal barrier epithelial cells and endothelial cells to promote homeostasis and repair. Expected outcomes of this project will be the identification of new molecules for future drug and vaccine development to improve gut health in mammals. This could provide significant downstream benefits to the Australian population and livestock industry through improved protection against cancer and intestinal infections, as well as increased productivity.","funding-current":1156024.00,"funding-at-announcement":1131556,"investigators-current":[{"title":"A/Prof","firstName":"Lisa","familyName":"Mielke","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0002-9522-9320 "}],"investigators-at-announcement":[{"title":"A/Prof","firstName":"Lisa","familyName":"Mielke","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0002-9522-9320 "}],"organisations-current":[{"organisationName":"La Trobe University","roleName":"Administering Organisation","state":"VIC"}],"organisations-at-announcement":[{"organisationName":"La Trobe University","roleName":"Administering Organisation","state":"VIC"}],"field-of-research":[{"isPrimary":true,"code":"3204","name":"Immunology","type":"FOR20"},{"isPrimary":false,"code":"320404","name":"Cellular Immunology","type":"FOR20"},{"isPrimary":false,"code":"320407","name":"Innate Immunity","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"}],"international-collaboration":["United States of America"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"As the centre of our digestive system, the intestine suffers daily damage from chemicals and pathogens in the food that we eat. Consequently, to maintain proper function it must constantly repair itself. Though vital to our gut function and our survival, these repair processes remain poorly understood and present a significant knowledge gap. Recent evidence suggests that immune cells play a key role in these processes. Using novel research tools, this project will uncover the critical communication networks between these immune cells and other cell types that make up our gut that control these repair processes. The knowledge generated in this project will position Australia to in future develop next-generation therapeutics and vaccines that promote intestinal health and defend against disease and infection. These emerging industries, projected to be worth more than 2 billion dollars by 2028, represent considerable economic and job-creating opportunities for Australia. The project findings will also inform new avenues to protecting both the Australian population and the livestock industry through improved disease prevention and increased productivity. To ensure the project outcomes are translated they will be shared with the broader community at open research forums, by press releases, public lectures and consumer meetings."}}}