{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/FT250100508"},"data":{"type":"grant-details","id":"FT250100508","attributes":{"code":"FT250100508","administering-organisation":"The University of Melbourne","announcement-administering-organisation":"The University of Melbourne","scheme-name":"ARC Future Fellowships","grant-status":"Active","funding-commencement-year":2025,"years-funded":4,"project-start-date":"2026-01-01","anticipated-end-date":"2029-12-31","grant-summary":"Understanding the cell and molecular processes directing memory T cell fate. This proposal aims to define the key cellular processes driving effective T cell-mediated immunity. Immune protection is mediated by the formation of distinct T cell subsets, each serving specific roles. By leveraging advanced expertise, techniques, and multidisciplinary collaborations, this project will dissect the processes underlying the differentiation of these memory T cell subsets. The outcomes of this proposal will facilitate further discovery and innovation in T cell biology, and accelerate life science research in Australia. Moreover, since T cell biology is relevant to all vertebrates, the findings from this work may have far-reaching implications, benefiting the conservation of threatened species, biosecurity and agriculture.","funding-current":990157.00,"funding-at-announcement":969312,"investigators-current":[{"title":"Dr","firstName":"Pirooz","familyName":"Zareie","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0001-6000-2305 "}],"investigators-at-announcement":[{"title":"Dr","firstName":"Pirooz","familyName":"Zareie","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0001-6000-2305 "}],"organisations-current":[{"organisationName":"The University of Melbourne","roleName":"Administering Organisation","state":"VIC"}],"organisations-at-announcement":[{"organisationName":"The University of Melbourne","roleName":"Administering Organisation","state":"VIC"}],"field-of-research":[{"isPrimary":true,"code":"3204","name":"Immunology","type":"FOR20"},{"isPrimary":false,"code":"320404","name":"Cellular Immunology","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"}],"international-collaboration":["United States of America"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"My research investigates how certain immune cells, called T cells, decide whether to become a circulating T cell which stay in the vasculature or take up long-term residence in tissues as tissue-resident memory T cells, which provide rapid, localized protection against infections that might reappear in those areas. This project addresses a critical research gap by investigating the detailed cellular and molecular mechanisms that direct T cell fate decisions. Through the development and utilisation of cutting-edge technologies, this project will dissect how these cellular processes contribute to memory T cell lineage choice. The insights from this research have wide-reaching implications, advancing our understanding of immune cell behaviour and potentially driving innovation in biotechnology and immunology. Through continued fundamental advances in our understanding of immune regulation, this project may also have potential to extend beyond cell biology and address other major challenges, including the agricultural control of emerging infectious diseases and improving the biosecurity of Australia. To extend the impact of my research beyond academia, I will promote research outcomes through public forums, lectures, and strategic collaborations with industry partners. All publications will be freely accessible through open access platforms and public repositories."}}}