{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/FT250100460"},"data":{"type":"grant-details","id":"FT250100460","attributes":{"code":"FT250100460","administering-organisation":"La Trobe University","announcement-administering-organisation":"Monash University","scheme-name":"ARC Future Fellowships","grant-status":"Active","funding-commencement-year":2025,"years-funded":4,"project-start-date":"2026-01-01","anticipated-end-date":"2029-12-31","grant-summary":" Unveiling the order of the gamma delta T cell immune synapse. B cells, ab T cells and gd T cells have co-evolved for 500 million years to fulfil unique roles. gd T cells have central roles in vertebrate development and immune defence. Poor understanding of gd T cell activation means these cells remain enigmatic and an immune research frontier. I will use cutting-edge cryo-electron and lattice-light sheet microscopy to answer this. Expected outcomes include molecular clarity of gd T cell triggers. Detail of gd T cell signalling cascades in concert with in situ studies will define how this immune cell lineage is activated. These discoveries will inform future immune and health research. This work will yield influential publications, foster international collaborations and advanced microscopy training.","funding-current":996487.00,"funding-at-announcement":975427,"investigators-current":[{"title":"Dr","firstName":"Benjamin","familyName":"Gully","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0002-8197-0871 "}],"investigators-at-announcement":[{"title":"Dr","firstName":"Benjamin","familyName":"Gully","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0002-8197-0871 "}],"organisations-current":[{"organisationName":"La Trobe University","roleName":"Administering Organisation","state":"VIC"}],"organisations-at-announcement":[{"organisationName":"Monash University","roleName":"Administering Organisation","state":"VIC"}],"field-of-research":[{"isPrimary":true,"code":"3101","name":"Biochemistry and Cell Biology","type":"FOR20"},{"isPrimary":false,"code":"310110","name":"Receptors and Membrane Biology","type":"FOR20"},{"isPrimary":false,"code":"310112","name":"Structural Biology (Incl. MacRomolecular Modelling)","type":"FOR20"},{"isPrimary":false,"code":"320404","name":"Cellular Immunology","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"}],"international-collaboration":["England"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"The immune system contains a variety of cell types with specific roles. One of these cell types, gamma delta T cells, are a unique type of white blood cell. These cells surveil the body to find ‘stressed’ cells that are not functioning properly. This fellowship will increase our understanding of how these cells are switched on in an immune response. This knowledge will offer new tools that could be used to turn on or turn off gamma delta T cells. This is important to understand how these cells function in development and health. The outcomes include future biotechnology linkages to develop gamma delta T cell immunotherapies. Thus contributing to both health and the Australian economy. These cells are abundant in humans, sheep, cattle and Australasian marsupials. Understanding how these cells function will be informative for their study in vertebrate immunity and health broadly. Thus, these discoveries will benefit Australian agriculture and efforts to protect fauna. "}}}