{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/FT250100365"},"data":{"type":"grant-details","id":"FT250100365","attributes":{"code":"FT250100365","administering-organisation":"Monash University","announcement-administering-organisation":"Monash University","scheme-name":"ARC Future Fellowships","grant-status":"Active","funding-commencement-year":2025,"years-funded":4,"project-start-date":"2025-11-01","anticipated-end-date":"2029-12-24","grant-summary":"How Does Ageing Affect GPCR Signalling: Focusing on Pro-resolving Receptors. G-protein-coupled receptors (GPCRs) are evolutionarily conserved cell surface proteins crucial for regulating human and animal physiology by transmitting signals essential for growth and ageing. This project aims to unravel the molecular mechanisms underlying GPCR-mediated signalling in physiological ageing, utilizing state-of-the-art experimental methods and multi-omics platforms. By exploring GPCR-driven cellular biology and dynamics in both 'young' and 'aged' systems, the project seeks to transform our understanding of mammalian ageing. The outcomes will advance biological knowledge, foster interdisciplinary collaborations, and promote cutting-edge research training, placing Australia at the forefront of global life sciences innovation. ","funding-current":1155384.00,"funding-at-announcement":1130932,"investigators-current":[{"title":"Dr","firstName":"Chengxue","familyName":"Qin","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0003-2169-2686 "}],"investigators-at-announcement":[{"title":"Dr","firstName":"Chengxue","familyName":"Qin","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0003-2169-2686 "}],"organisations-current":[{"organisationName":"Monash University","roleName":"Administering Organisation","state":"VIC"}],"organisations-at-announcement":[{"organisationName":"Monash University","roleName":"Administering Organisation","state":"VIC"}],"field-of-research":[{"isPrimary":false,"code":"310110","name":"Receptors and Membrane Biology","type":"FOR20"},{"isPrimary":false,"code":"310910","name":"Animal Physiology - Systems","type":"FOR20"},{"isPrimary":true,"code":"3214","name":"Pharmacology and Pharmaceutical Sciences","type":"FOR20"},{"isPrimary":false,"code":"321401","name":"Basic Pharmacology","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"},{"code":"280105","name":"Expanding Knowledge In the Chemical Sciences","type":"SEO20"}],"international-collaboration":["Ireland","Singapore"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"This project seeks to elucidate the fundamental role of GPCRs in mammalian ageing, addressing a critical knowledge gap in how GPCR-mediated cellular processes adapt and change with age. By investigating age-related alterations in GPCR signalling, particularly in impaired inflammation resolution, this research seeks to advance our understanding of the molecular mechanisms underlying ageing-related physiological and cellular processes. The study will focus on how these changes affect the integrity of vital biological systems, offering insights into GPCR signalling at both the cellular and organismal levels during ageing. \n\nThis research aims to identify novel molecular markers to modulate GPCR pathways, potentially enhancing healthy ageing. While advancing scientific knowledge, it may inform strategies to mitigate ageing-related decline. Given Australia's rising economic burden from its ageing population (~$36 billion/year), the findings are timely and relevant, addressing both scientific and societal challenges. Our findings will be shared through industry collaborations, publications, and presentations, promoting broad academic impact. Engaging with the biotechnology and pharmaceutical sectors, the project will drive innovation in GPCR research, developing new cellular and physiology platforms to study GPCR in the ageing context. It will also strengthen international partnerships, enhancing Australia's global competitiveness in life sciences and ageing research."}}}