{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/FT250100334"},"data":{"type":"grant-details","id":"FT250100334","attributes":{"code":"FT250100334","administering-organisation":"Monash University","announcement-administering-organisation":"Monash University","scheme-name":"ARC Future Fellowships","grant-status":"Active","funding-commencement-year":2025,"years-funded":4,"project-start-date":"2026-06-30","anticipated-end-date":"2030-06-29","grant-summary":"Understanding the role of meningeal barriers in brain immune privilege. This project investigates how the arachnoid barrier in the meninges supports immune privilege, protecting the brain from inflammatory damage. This project will explore arachnoid barrier function and dysfunction to open up a new frontier that unravels the fundamental principles that regulate neuro-immune interactions to safeguard the brain. This interdisciplinary study will offer paradigm-shifting insights into the communication between the nervous and immune systems, transforming our understanding of how the immune system and nervous system interact. These findings will pave the way to harness these protective mechanisms, with future applications that will help protect brain health and preserve brain function during healthy aging.","funding-current":997813.00,"funding-at-announcement":976696,"investigators-current":[{"title":"Dr","firstName":"Leon","familyName":"Smyth","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0001-9861-3574 "}],"investigators-at-announcement":[{"title":"Dr","firstName":"Leon","familyName":"Smyth","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0001-9861-3574 "}],"organisations-current":[{"organisationName":"Monash University","roleName":"Administering Organisation","state":"VIC"}],"organisations-at-announcement":[{"organisationName":"Monash University","roleName":"Administering Organisation","state":"VIC"}],"field-of-research":[{"isPrimary":true,"code":"3109","name":"Zoology","type":"FOR20"},{"isPrimary":false,"code":"310910","name":"Animal Physiology - Systems","type":"FOR20"},{"isPrimary":false,"code":"320404","name":"Cellular Immunology","type":"FOR20"},{"isPrimary":false,"code":"320902","name":"Cellular Nervous System","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"}],"international-collaboration":["Singapore","United States of America"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"Immune privilege is critical to protecting the brain from immune attack but little is known about the mechanisms that govern it. Indeed, many neurological diseases have a significant immune component, suggesting that dysfunction in immune privilege contributes to disease. This project focus on the role of the arachnoid barrier, an important but understudied neuroimmune interface, that defines the boundary of immune privilege in the CNS. Novel tools will be employed to dissect how the arachnoid barrier regulates neuroimmune interactions and identify mechanisms that trigger dysfunction. The aging population presents a major challenge in developed countries, in part because brain function diminishes during aging. The immune system plays an important role in brain aging, and understanding the principles of neuroimmune interactions will enable biotechnology to harness these to preserve healthy brain function and resilience during aging. We will ensure the dissemination of our findings through engagement with the public in lectures, articles, and through social media, as well as experts through seminars, conferences, and publications. As the population ages, and the prevalence of neurological diseases rises, understanding these processes will be critical to maintain the health and well-being of Australians, and their participation in the economy."}}}