{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/FT250100313"},"data":{"type":"grant-details","id":"FT250100313","attributes":{"code":"FT250100313","administering-organisation":"The University of Queensland","announcement-administering-organisation":"The University of Queensland","scheme-name":"ARC Future Fellowships","grant-status":"Active","funding-commencement-year":2025,"years-funded":4,"project-start-date":"2026-06-30","anticipated-end-date":"2031-09-30","grant-summary":"Go & grow - uncovering mechanism coupling cell proliferation and migration. This project aims to investigate how cells coordinate proliferation and migration, key processes for tissue formation. Challenging the current understanding that cell proliferation and migration are mutually exclusive, the project hypothesises that the boundary between them is fluid, allowing for greater plasticity in tissue formation. By combining advanced genomics, classical genetics, and live imaging techniques, this project will identify the molecular mechanisms enabling the switch between these processes. Expected outcomes include establishing new paradigms in cell and developmental biology, with potential advancements in biotechnology, tissue engineering, and organismal adaptability, driving economic growth while expanding knowledge.","funding-current":1156175.00,"funding-at-announcement":1131704,"investigators-current":[{"title":"Dr","firstName":"Katarzyna","familyName":"Koltowska","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0002-6841-8900 "}],"investigators-at-announcement":[{"title":"Dr","firstName":"Katarzyna","familyName":"Koltowska","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0002-6841-8900 "}],"organisations-current":[{"organisationName":"The University of Queensland","roleName":"Administering Organisation","state":"QLD"}],"organisations-at-announcement":[{"organisationName":"The University of Queensland","roleName":"Administering Organisation","state":"QLD"}],"field-of-research":[{"isPrimary":true,"code":"3101","name":"Biochemistry and Cell Biology","type":"FOR20"},{"isPrimary":false,"code":"310102","name":"Cell Development, Proliferation and Death","type":"FOR20"},{"isPrimary":false,"code":"310204","name":"Genomics and Transcriptomics","type":"FOR20"},{"isPrimary":false,"code":"310503","name":"Developmental Genetics (Incl. Sex Determination)","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"}],"international-collaboration":["Finland","Sweden"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"This research aims to uncover how cells coordinate cell proliferation and migration during tissue formation, challenging the current belief that these processes are mutually exclusive. By studying lymphatic endothelial cells, this project seeks to define the molecular mechanisms that allow cells to rapidly transition from a proliferative to a migratory state. Understanding this cellular plasticity could transform fields such as tissue engineering, biotechnology and organismal adaptability.\nThis research has the potential to drive economic, commercial and environmental benefits. In biotechnology, the findings could lead to innovations in developing synthetic tissues and materials that mimic natural processes. Tissue repair and regeneration is an essential process spanning both plant and animal biology. Uncovering the underlying mechanisms of this process, such as cell proliferation and movement, has broad implications beyond developmental biology. Thus, this project has applications in agriculture, such as creating crops with enhanced growth and resilience, improving plant regeneration, and optimising growth in challenging climates. By translating this knowledge beyond academia, the project will contribute to Australia's leadership in biological research, driving innovation in environmental sustainability and biotechnology. To ensure widespread impact, the research outcomes will be shared through scientific publications, industry collaborations and public outreach."}}}