{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/FT250100051"},"data":{"type":"grant-details","id":"FT250100051","attributes":{"code":"FT250100051","administering-organisation":"The University of New South Wales","announcement-administering-organisation":"The University of New South Wales","scheme-name":"ARC Future Fellowships","grant-status":"Active","funding-commencement-year":2025,"years-funded":4,"project-start-date":"2025-07-01","anticipated-end-date":"2029-06-30","grant-summary":"Understanding the neural mechanisms underlying adaptive behaviour. Some species exhibit the ability to suitably adapt their behaviour in dynamic environments. A key gap in knowledge is how new experiences can be properly intertwined with pre-existing learning while avoiding interference and disarray. This project seeks to identify the cellular and circuit mechanisms underlying behavioural change. Using established behavioural tasks to measure memory interference, with cutting-edge neuroscience techniques for in vivo imaging and manipulation of brain circuits in behaving mice, this Fellowship aims to unravel how major neuromodulatory systems intersect to modify future behaviours. The translation of this work may lead to better ways to treat inflexible traits and to develop new adaptive artificial networks.","funding-current":1135338.00,"funding-at-announcement":1111567,"investigators-current":[{"title":"Dr","firstName":"Miriam","familyName":"Matamales","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0001-9978-0091 "}],"investigators-at-announcement":[{"title":"Dr","firstName":"Miriam","familyName":"Matamales","roleName":"Future Fellowship","roleCode":"FT","isFellowship":true,"orcidIdentifier":"0000-0001-9978-0091 "}],"organisations-current":[{"organisationName":"The University of New South Wales","roleName":"Administering Organisation","state":"NSW"}],"organisations-at-announcement":[{"organisationName":"The University of New South Wales","roleName":"Administering Organisation","state":"NSW"}],"field-of-research":[{"isPrimary":true,"code":"3109","name":"Zoology","type":"FOR20"},{"isPrimary":false,"code":"310901","name":"Animal Behaviour","type":"FOR20"},{"isPrimary":false,"code":"310906","name":"Animal Neurobiology","type":"FOR20"},{"isPrimary":false,"code":"320903","name":"Central Nervous System","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"}],"international-collaboration":["United States of America"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"This Fellowship will elucidate the processes that fine-tune brain circuits controlling behaviour. It will employ advanced methods in behavioural neuroscience and computational biology, to record and manipulate the activity and system dynamics of large ensembles of neurons. This in-depth knowledge can only be gained through the implementation of these sophisticated models and techniques, which are available in my laboratory. Understanding the mechanistic basis of adaptive behaviour is essential for comprehending how humans and non-human animals interact with an ever-changing environment. Accordingly, these findings are relevant to disorders characterised by maladaptive and inflexible traits. Moreover, outcomes from this Fellowship will inform those working at the frontiers of systems engineering and learning theory, and may help develop novel biologically-inspired neural networks. Finally, this Fellowship will facilitate interdisciplinary training for emerging scientists and collaboration with international partners, strengthening Australia's international scientific reputation."}}}