{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/DE260101958"},"data":{"type":"grant-details","id":"DE260101958","attributes":{"code":"DE260101958","administering-organisation":"The University of New South Wales","announcement-administering-organisation":"The University of New South Wales","scheme-name":"Discovery Early Career Researcher Award","grant-status":"Active","funding-commencement-year":2026,"years-funded":3,"project-start-date":"2026-01-01","anticipated-end-date":"2026-01-01","grant-summary":"Spatial proteomics of immune cell surfaceome at single protein resolution. The proposed fellowship will focus on developing a state-of-the-art nanoscopic spatial proteomics platform for multiplexed quantitative imaging of eukaryotic immune cell surface proteins at nanometre spatial and millisecond temporal resolutions. This will be achieved using multiplexed super-resolved DNA-based points accumulation for imaging nanoscale topography and lattice light-sheet microscopy. Using these technologies, the final goal is to visualise receptor organisation on cell membranes and cell-cell junctions, particularly immunological synapses. Given the central role of receptors in cell signalling, a molecular atlas of receptors at single receptor resolution will provide valuable new insights into receptor research.","funding-current":0.00,"funding-at-announcement":515079,"investigators-current":[{"title":"Dr","firstName":"Arindam","familyName":"Ghosh","roleName":"Discovery Early Career Researcher Award","roleCode":"DECRA","isFellowship":true,"orcidIdentifier":"0000-0002-5712-1271 "}],"investigators-at-announcement":[{"title":"Dr","firstName":"Arindam","familyName":"Ghosh","roleName":"Discovery Early Career Researcher Award","roleCode":"DECRA","isFellowship":true,"orcidIdentifier":"0000-0002-5712-1271 "}],"organisations-current":[{"organisationName":"The University of New South Wales","roleName":"Administering Organisation","state":"NSW"}],"organisations-at-announcement":[{"organisationName":"The University of New South Wales","roleName":"Administering Organisation","state":"NSW"}],"field-of-research":[{"isPrimary":false,"code":"310110","name":"Receptors and Membrane Biology","type":"FOR20"},{"isPrimary":true,"code":"3208","name":"Medical Physiology","type":"FOR20"},{"isPrimary":false,"code":"320802","name":"Human Biophysics","type":"FOR20"},{"isPrimary":false,"code":"340605","name":"Molecular Imaging (Incl. Electron Microscopy and Neutron Diffraction)","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"},{"code":"280103","name":"Expanding Knowledge In the Biomedical and Clinical Sciences","type":"SEO20"},{"code":"280120","name":"Expanding Knowledge In the Physical Sciences","type":"SEO20"}],"international-collaboration":["Germany","United States of America"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"This DECRA project will investigate how eukaryotic cell membrane proteins self-organise and interact with ligands at the molecular scale. Specifically, the project will utilise state-of-the-art fluorescence imaging tools to visualise the molecular distribution of receptors on immune cell surfaces at single protein resolution. These receptors are target biomarkers in anticancer immunotherapies. Hence, the availability of a three-dimensional global atlas of the cell surface proteome or cell surfaceome will aid clinicians in finding new targets and designing refined immunotherapies. The project addresses the research gap between core clinical research and basic biomedical research in Australia. Haematological cancers are Australia's second-most diagnosed cancer and the third biggest cause of cancer deaths. In 2024, around 20,044 Australians were diagnosed with blood cancers. Therefore, by providing detailed insights on therapy-relevant target proteins on the cancer cell surface, this project will substantially contribute to health, social, and economic benefits for Australians."}}}