{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/DE260101797"},"data":{"type":"grant-details","id":"DE260101797","attributes":{"code":"DE260101797","administering-organisation":"Griffith University","announcement-administering-organisation":"Griffith University","scheme-name":"Discovery Early Career Researcher Award","grant-status":"Active","funding-commencement-year":2026,"years-funded":3,"project-start-date":"2026-01-01","anticipated-end-date":"2028-12-31","grant-summary":"Beyond Symmetry: Unravelling glyco-modulation of the immune system. This project aims to use state-of-the-art biological and chemical approaches to unveil how antibody glycosylation modulates the immune system. This project expects to generate new knowledge on the mechanisms modulating the immune response not yet addressed by current research. Expected outcomes include the identification of relationships between specific glycosylation states and certain immune responses. Benefits should include new knowledge improving our fundamental understanding of the antibody-mediated immune response. The outcomes will lead to future economic opportunities by tailoring monoclonal antibody production towards better efficiency. ","funding-current":531296.00,"funding-at-announcement":527079,"investigators-current":[{"title":"Dr","firstName":"Jonathan","familyName":"Du","roleName":"Discovery Early Career Researcher Award","roleCode":"DECRA","isFellowship":true,"orcidIdentifier":"0000-0002-7750-4413 "}],"investigators-at-announcement":[{"title":"Dr","firstName":"Jonathan","familyName":"Du","roleName":"Discovery Early Career Researcher Award","roleCode":"DECRA","isFellowship":true,"orcidIdentifier":"0000-0002-7750-4413 "}],"organisations-current":[{"organisationName":"Griffith University","roleName":"Administering Organisation","state":"QLD"}],"organisations-at-announcement":[{"organisationName":"Griffith University","roleName":"Administering Organisation","state":"QLD"}],"field-of-research":[{"isPrimary":true,"code":"3101","name":"Biochemistry and Cell Biology","type":"FOR20"},{"isPrimary":false,"code":"310107","name":"Glycobiology","type":"FOR20"},{"isPrimary":false,"code":"310112","name":"Structural Biology (Incl. MacRomolecular Modelling)","type":"FOR20"},{"isPrimary":false,"code":"320502","name":"Medical Biochemistry - Carbohydrates","type":"FOR20"}],"socio-economic-objective":[{"code":"200101","name":"Diagnosis of Human Diseases and Conditions","type":"SEO20"},{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"},{"code":"280103","name":"Expanding Knowledge In the Biomedical and Clinical Sciences","type":"SEO20"}],"international-collaboration":["United States of America"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"The human immune response is essential for survival, yet a critical knowledge gap remains in understanding how its type and magnitude are modulated. While specific modifications known as glycosylation of Immunoglobulin G (IgG) antibodies are known to regulate the immune response, it is not yet fully understood how individual glycosylation features influence response type and magnitude, shaping immune reactions to threats. This project addresses this gap by applying a combination of advanced biological and chemical techniques to systematically study how IgG glycosylation modulates the interaction with their receptors and their functional consequences. The knowledge developed in this project will not just generate novel insights into the glycosylation-dependent regulation of the immune response but will also expand our fundamental understanding of human biology. The knowledge and outcomes of this project will benefit fundamental immunology research as well as biotechnology industry applications and will find future applications in precision medicine and treatment. These outcomes will further strengthen Australia’s leading global role in fundamental and applied glycosciences and their role within the immune system. The knowledge from this project will be shared with the wider scientific community and to the public through social media and explanatory articles in The Conversation."}}}