{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/DE260101401"},"data":{"type":"grant-details","id":"DE260101401","attributes":{"code":"DE260101401","administering-organisation":"Griffith University","announcement-administering-organisation":"Griffith University","scheme-name":"Discovery Early Career Researcher Award","grant-status":"Active","funding-commencement-year":2026,"years-funded":3,"project-start-date":"2026-01-01","anticipated-end-date":"2028-12-31","grant-summary":"Harnessing glycomics to dissect virus-mosquito interaction and transmission. This project aims to investigate the role of carbohydrate molecules on viruses and mosquito cells in influencing infection, replication, and spread within mosquitos. How these interactions impact the transmission of mosquito-borne viruses will be examined. Using state-of-the-art spatial biology and glycomics, the project aims to uncover molecular mechanisms by which viruses interact with cell surface receptors, utilise mosquito host factors for replication, and spread within mosquito tissues, ultimately shaping transmission to mammalian hosts. This research should advance understanding of virus-mosquito biology, support antiviral development, and improve public health preparedness through better surveillance and mosquito control strategies.","funding-current":501984.00,"funding-at-announcement":498079,"investigators-current":[{"title":"Dr","firstName":"Xiang","familyName":"Liu","roleName":"Discovery Early Career Researcher Award","roleCode":"DECRA","isFellowship":true,"orcidIdentifier":"0000-0002-8165-3294 "}],"investigators-at-announcement":[{"title":"Dr","firstName":"Xiang","familyName":"Liu","roleName":"Discovery Early Career Researcher Award","roleCode":"DECRA","isFellowship":true,"orcidIdentifier":"0000-0002-8165-3294 "}],"organisations-current":[{"organisationName":"Griffith University","roleName":"Administering Organisation","state":"QLD"}],"organisations-at-announcement":[{"organisationName":"Griffith University","roleName":"Administering Organisation","state":"QLD"}],"field-of-research":[{"isPrimary":false,"code":"310107","name":"Glycobiology","type":"FOR20"},{"isPrimary":true,"code":"3107","name":"Microbiology","type":"FOR20"},{"isPrimary":false,"code":"310706","name":"Virology","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"}],"international-collaboration":["Brazil","Estonia","United States of America"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"Mosquito-borne viruses pose a growing global health and economic threat, with diseases like dengue, Zika, and Chikungunya affecting millions. In Australia, mosquito populations are expanding due to climate change and human migration, escalating the nation’s biosecurity risk. This expanding habitat, coupled with the rapid adaptation of viruses to new vectors, increases the likelihood of spillover into new environments and underscores the urgent need for better surveillance and control strategies. However, our ability to prevent outbreaks is limited by poor understanding of how viruses interact with mosquito vectors. This research will generate critical knowledge on the glycomic mechanisms that govern virus-mosquito interactions. It will drive the development of precise vector control strategies, and contribute to next-generation surveillance technologies with economic benefits. Aligned with national science priorities in biosecurity and health, this project enhances Australia’s pandemic preparedness and positions the country as a global leader in arbovirus research. Additionally, the project aligns with five of six pillars of the WHO Global Arbovirus Initiative, including monitoring risk, reducing epidemic risk, strengthening vector control, and preparing for pandemics. To maximise understanding and adoption beyond academia, I will engage with public health agencies and community stakeholders through targeted outreach, policy briefs, and collaborative platforms."}}}