{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/DE260101179"},"data":{"type":"grant-details","id":"DE260101179","attributes":{"code":"DE260101179","administering-organisation":"La Trobe University","announcement-administering-organisation":"La Trobe University","scheme-name":"Discovery Early Career Researcher Award","grant-status":"Active","funding-commencement-year":2026,"years-funded":3,"project-start-date":"2026-01-01","anticipated-end-date":"2028-12-31","grant-summary":"Revealing the role of gut-bacterial amyloids in human ageing. The biology of ageing is dependent on various biochemical processes. Recent evidence suggests that gut-bacteria can influence these ageing-associated processes, in turn impacting the quality of ageing and productivity in later stages of life. This project aims to investigate how components from microbial biofilms, termed amyloids, leach out from the gut, access other tissues and interfere with cellular and molecular processes involved in ageing. It will generate new knowledge on ageing biology in relation to gut-bacteria. Expected outcomes include conceptual insights in gut-microbiome-human communications with social benefits to improve the quality of ageing in senior citizens and Australia’ economic capacity in aged-care services.","funding-current":512935.00,"funding-at-announcement":508923,"investigators-current":[{"title":"Dr","firstName":"Ibrahim","familyName":"Javed","roleName":"Discovery Early Career Researcher Award","roleCode":"DECRA","isFellowship":true,"orcidIdentifier":"0000-0003-1101-5614 "}],"investigators-at-announcement":[{"title":"Dr","firstName":"Ibrahim","familyName":"Javed","roleName":"Discovery Early Career Researcher Award","roleCode":"DECRA","isFellowship":true,"orcidIdentifier":"0000-0003-1101-5614 "}],"organisations-current":[{"organisationName":"La Trobe University","roleName":"Administering Organisation","state":"VIC"}],"organisations-at-announcement":[{"organisationName":"La Trobe University","roleName":"Administering Organisation","state":"VIC"}],"field-of-research":[{"isPrimary":true,"code":"3404","name":"Medicinal and Biomolecular Chemistry","type":"FOR20"},{"isPrimary":false,"code":"340407","name":"Proteins and Peptides","type":"FOR20"},{"isPrimary":false,"code":"401807","name":"Nanomaterials","type":"FOR20"},{"isPrimary":false,"code":"510501","name":"Biological Physics","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"}],"international-collaboration":["Denmark","United States of America"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"The size of Australia’s ageing population is growing, with more than 22% over 65 by 2026. While a person’s quality of life during ageing depends on certain inherent biochemical processes, remarkably gut bacteria are emerging as a critical factor in how we age. How gut-bacteria communicate with human hosts, how they affect biochemical processes of ageing and whether gut-bacteria can be manipulated to achieve healthy ageing, is unknown. My previous research indicates that specific molecules (amyloids) produced by certain gut-bacteria can trigger aggregation in human proteins, a hallmark of ageing, in turn potentially silently accelerating the biochemistry of ageing in an otherwise healthy host. This DECRA aims to discover how bacterial amyloids are linked with the biology of human ageing. This project will generate fundamental knowledge on the human gut-microbiome and its impact on ageing, in turn advancing the state-of-the-art to selectively exploit the gut-microbiome for healthy ageing. The social benefits will potentially provide additional active years in the life of senior Australian citizens and strengthen Australia’s economic capacity in aged-care services. The outcomes will be communicated to local industry through conferences and networking events and to the community through podcasts, radio/tv interviews and public magazines."}}}