{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/DE260100449"},"data":{"type":"grant-details","id":"DE260100449","attributes":{"code":"DE260100449","administering-organisation":"The University of Melbourne","announcement-administering-organisation":"The University of Melbourne","scheme-name":"Discovery Early Career Researcher Award","grant-status":"Active","funding-commencement-year":2026,"years-funded":3,"project-start-date":"2026-01-01","anticipated-end-date":"2028-12-31","grant-summary":"Multiscale mathematical modelling of menstrual cycle dynamics. This interdisciplinary project aims to develop novel mathematical models to unify understanding of how key components of the menstrual cycle interact to regulate healthy function. The project’s goal is to use these models to establish a baseline definition of a healthy menstrual cycle and normal variation, and to gain new understanding into how immune response varies with cycle phase and reproductive age. Expected outcomes of the project include new mathematical techniques that will be widely useful for applications in biology, and a new approach to understanding female physiology. This is anticipated to provide a powerful tool for future uterine research, placing Australia as a leader in novel approaches to understanding Women’s Health.","funding-current":526527.00,"funding-at-announcement":522317,"investigators-current":[{"title":"Dr","firstName":"Claire","familyName":"Miller","roleName":"Discovery Early Career Researcher Award","roleCode":"DECRA","isFellowship":true,"orcidIdentifier":"0000-0003-0758-9447 "}],"investigators-at-announcement":[{"title":"Dr","firstName":"Claire","familyName":"Miller","roleName":"Discovery Early Career Researcher Award","roleCode":"DECRA","isFellowship":true,"orcidIdentifier":"0000-0003-0758-9447 "}],"organisations-current":[{"organisationName":"The University of Melbourne","roleName":"Administering Organisation","state":"VIC"}],"organisations-at-announcement":[{"organisationName":"The University of Melbourne","roleName":"Administering Organisation","state":"VIC"}],"field-of-research":[{"isPrimary":true,"code":"4901","name":"Applied Mathematics","type":"FOR20"},{"isPrimary":false,"code":"490102","name":"Biological Mathematics","type":"FOR20"}],"socio-economic-objective":[{"code":"200509","name":"Women'S and Maternal Health","type":"SEO20"},{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"},{"code":"280118","name":"Expanding Knowledge In the Mathematical Sciences","type":"SEO20"}],"international-collaboration":["Canada","New Zealand"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"This project will build the first complete mathematical model of the menstrual cycle, encompassing the different stages of the reproductive lifetime from menarche (first period) though to menopause, a pivotal step in resolving the current severe deficit in our understanding of female physiology. Only with a comprehensive understanding of the key biological systems involved in the menstrual cycle will we be able to fully understand the dysfunctions that lead to gynaecological diseases, which have been estimated to cost the Australian economy over $7 billion annually. This project will address this research gap by building an understanding of how key physiological systems are regulated over the menstrual cycle using mathematical modelling. With a model developed, hypotheses for dysfunction will emerge which will guide future health and medical research into diseases such as endometriosis. This foundational project will develop novel mathematical approaches to address a high priority research area in mathematical biology: integration of data and mathematical models that span multiple spatial and temporal scales. This project will elevate Australia to be the world-leader in mathematical modelling applied to gynaecology. Results of the project will be freely available to the public and downstream medical researchers through open-access publishing, and through accessible non-academic avenues such as scientific commentaries, promoting women’s understanding of their own physiology."}}}