{"links":{"self":"http://dataportal.arc.gov.au/NCGP/API/grants/DE260100279"},"data":{"type":"grant-details","id":"DE260100279","attributes":{"code":"DE260100279","administering-organisation":"Monash University","announcement-administering-organisation":"Monash University","scheme-name":"Discovery Early Career Researcher Award","grant-status":"Active","funding-commencement-year":2026,"years-funded":3,"project-start-date":"2026-12-31","anticipated-end-date":"2029-12-30","grant-summary":"The mechanistic basis of how bacteria respond to environmental change. The bacterial cell surface is the primary barrier that protects from external threats; however, it remains unclear how bacteria rapidly remodel this protective layer. This project aims to discover the mechanisms by which bacteria rapidly respond to changes in their local environment. The project expects to define these mechanisms using  combinations of molecular analysis, cutting-edge nanoscale imaging, genome-wide profiling and AI-driven structural analysis. Expected outcomes are to understand this fundamental biological principle and advance our knowledge of bacterial cell biology and environmental adaptation. The findings from this project should provide significant benefits for the global research community and commercial biotechnology.","funding-current":515103.00,"funding-at-announcement":511024,"investigators-current":[{"title":"Dr","firstName":"Thomas","familyName":"McLean","roleName":"Discovery Early Career Researcher Award","roleCode":"DECRA","isFellowship":true,"orcidIdentifier":"0000-0002-6467-4974 "}],"investigators-at-announcement":[{"title":"Dr","firstName":"Thomas","familyName":"McLean","roleName":"Discovery Early Career Researcher Award","roleCode":"DECRA","isFellowship":true,"orcidIdentifier":"0000-0002-6467-4974 "}],"organisations-current":[{"organisationName":"Monash University","roleName":"Administering Organisation","state":"VIC"}],"organisations-at-announcement":[{"organisationName":"Monash University","roleName":"Administering Organisation","state":"VIC"}],"field-of-research":[{"isPrimary":true,"code":"3101","name":"Biochemistry and Cell Biology","type":"FOR20"},{"isPrimary":false,"code":"310110","name":"Receptors and Membrane Biology","type":"FOR20"},{"isPrimary":false,"code":"310111","name":"Signal Transduction","type":"FOR20"},{"isPrimary":false,"code":"310112","name":"Structural Biology (Incl. MacRomolecular Modelling)","type":"FOR20"}],"socio-economic-objective":[{"code":"280102","name":"Expanding Knowledge In the Biological Sciences","type":"SEO20"}],"international-collaboration":["England","Germany","Japan","Scotland","United States of America"],"lief-register":[],"achievement-summary":null,"national-interest-test-statement":"Bacteria can live in environments which change quickly from one extreme to another, and climate change impacts on these changes. Bacteria must respond rapidly to these changes or risk perishing, and this project addresses the means by which bacteria can reprogram their properties in response to the environment. Australia has moved to the forefront of studies addressing this newly recognized process in bacterial cell biology. Training of new research staff and students in this arena provides a means for career development in the pursuit of knowledge using a wide array of technologies drawn from disciplines ranging from genomics to microbiology to RNA biology to biochemistry and membrane biology, and the research could provide benefits in biotechnology, food security and other commercially important sectors. The insights gained will be shared widely with the international research community and will be publicised through social media channels, scientific conferences and seminars, local newspapers and magazines to maximise the use and adoption of the research in the future, further enhancing Australia’s reputation for world-class biological research. "}}}